I discovered by accident when I started wearing sunglasses regularly in my late teens that my right ear is quite a bit lower than my left. I must admit it did take me a while to figure out why my glasses were always on a lean!
Apparently it's pretty common to not be symmetrical, which does make me feel a little better :)
So apart from looking wonky when I wear sunglasses the only other thing it affects is earrings - oh yes, one definately looks longer, but lets face it - who sits/stands bolt upright regularly unless you're in the armed forces right?
Generally I don't worry about it, forget about it even, but every so often I will make a pair of earrings that's a bit longer on one side, add an extra jump ring or, like my current favs below, I'll use a shell or component that is a bit longer for one of them.
If you're symmetrically ah... different... like me, don't be afraid to ask your fav jewellery designer to work their magic and tailor-make something to suit you :)